Jon Darkow's Work

We found 37 items

#1 - Lactase Enzyme Simulation with Data Analysis

by Jon Darkow - 81865 runs
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#2 - Photosynthesis Model

by Jon Darkow - 32783 runs
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#3 - Population dynamics of white footed mouse

by Jon Darkow - 15981 runs
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#4 - Cellular Respiration Accounting Model

by Jon Darkow - 6345 runs
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The purpose of the model is to understand how glucose is metabolized, and how the energy stored in its chemical bonds is transfered.

#5 - Apterous Genetics

by Jon Darkow - 7002 runs
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Apterous is an allele that results in a fly without wings. Wild-type variants have normally functioning wings. The goal of this simulation is to determine the pattern of inheritance for the apterous phenotype. Is apterous dominant or recessive? Sex-linked or autosomal? Complete, incomplete, or codominant?

#6 - Water Potential and Osmosis

by Jon Darkow - 3099 runs
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Factors that affect the flow across a semi-permeable membrane.

#7 - Steady State in Freshwater Ecosystems

by Jon Darkow - 2505 runs
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#8 - White-Eyed Genetics

by Jon Darkow - 3228 runs
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White-eyed is an allele that results in a fly white eyes. Wild-type variants have red eyes. The goal of this simulation is to determine the pattern of inheritance for the white-eyed phenotype. Is yellow body dominant or recessive? Sex-linked or autosomal? Complete, incomplete, or codominant?

#9 - Growth Factors, Cyclins, and Cancer

by Jon Darkow - 11302 runs
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Explores the feedback loops that regulate the cell cycle. Model focuses on manipulating stimuli (growth factors), to stimulate the cell cycle feedback loops.

#10 - Evolution

by Jon Darkow - 1206 runs
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Evolution of Populations: Genetic Drift, Natural Selection, and Mutations

#11 - HPV and Adaptive Immune Response

by Jon Darkow - 1029 runs
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#12 - Extinction Vortex

by Jon Darkow - 1051 runs
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#13 - Evolution of LAP Allele in Mussels

by Jon Darkow - 2892 runs
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#14 - Recombination and Gene Linkage

by Jon Darkow - 2164 runs
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#15 - Transformation Simulation

by Jon Darkow - 1032 runs
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Simulation allows students to test the transformation principle. Two major goals of the experiment are: 1. Allow users to see that supernatant from heat-killed bacteria can transform the genes of another bacterium. 2. What transforms the inheritance of the bacteria is DNA, not RNA or proteins.

#16 - Phenology of the Karner Blue Butterfly

by Jon Darkow - 242 runs
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Karner Blue butterfly is an endangered species. Habitat loss and climate change are contributing factors to the reduction in the butterflies' population sizes. Climate change can alter the timing of lifecycles. When climate change disproportionally affects the timing of life cycles of species in an ecosystem asynchrony within a food web occurs.

#17 - Trp Operon

by Jon Darkow - 1185 runs
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Tryptophan is an amino acid that is synthesized by plants and bacteria from other molecules in a biochemical pathway (see diagram below). The trypophan operon is a series of sequential genes found on a bacterial genome. The genes of the operon produce the enzymes that direct the synthesis of tryptophan. In this model you will experiment with the negative feedback loop of the repressible system.

#18 - Neurophysiology and Neurotoxicity

by Jon Darkow - 40 runs
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The main dependent variable measured in the model is the membrane potential (millivolts) of a motor neuron and the muscle fiber it innervates. You will be able to add excitatory and inhibitory neurotransmitters, and compare how neurotransmitters modulate the electrical impulses of the motor neuron and the muscle fiber. Additionally, you will be able to compare the effects of four neurotoxins: Tetrodotoxin, botulinum toxin, sarin nerve gas, and VX. While extremely lethal, these toxins are very instructive in understanding neurons because of the specific way the toxins act. Each toxin modifies or inhibits a specific molecule in neurons that help process and transmit information.

#19 - Lactose Operon: An Inducible System

by Jon Darkow - 5499 runs
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In this simulation users explore the negative feedback system of the Lactose Operon found in bacteria. Lactose induces the system by inhibiting and inhibitor.

#20 - Information Processing and Neurophysiology Model

by Jon Darkow - 16138 runs
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The main dependent variable measured in the model is the membrane potential (millivolts) of two different neurons in a series. You will be able to add excitatory and inhibitory neurotransmitters, and compare how these modulate electrical impulses of the two neurons. Additionally, you will be able to compare the effects of three neurotoxins: Tetrodotoxin, botulinum toxin, and sarin nerve gas. While extremely lethal, these toxins are very instructive in understanding neurons because of the specific way the toxins act. Each toxin modifies or inhibits a specific molecule in neurons that help process and transmit information.

#21 - Lactase with Variable Sample Sizes

by Jon Darkow - 199 runs
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Arrayed Lactase Model

#22 - Evolution: Grants Finches

by Jon Darkow - 129 runs
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Models the effects on population sizes of ground finches with different beak sizes in response to different amounts of annual precipitation.

#23 - Evolution and Natural Selection

by Jon Darkow - 7525 runs
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#24 - Lac Operon with Monod Bump

by Jon Darkow - 153 runs
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#25 - Logistic Growth Model and the Butterfly Effect

by Jon Darkow - 200 runs
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Model allows users to test the starting population size (N), the carrying capacity of the population (K), and the intrinsic rate of growth (r max). Iterations are discrete, not continuous.

#26 - Photosynthesis with Variable Sample Sizes

by Jon Darkow - 111 runs
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Sample sizes of Photosynthesis stocks in an array

#27 - Cellular Respiration Inquiry

by Jon Darkow - 16 runs
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Model of the dynamics of the metabolism of one mole of glucose. Randomness is built into the computations.

#28 - Chaos Theory: Strange Attractor

by Jon Darkow - 78 runs
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Manipulate the main variables of the Lorenz equation.

#29 - Tip

by Jon Darkow - 48 downloads
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#30 - Tick Tock: The Biological Clock and Circadian Rhythm

by Jon Darkow - 94 runs
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Explore gene expression of the transcriptional-translational feedback loop (TTFL) of the mouse circadian rhythm.

#31 - Thyroid Hormone - Negative Feedback

by Jon Darkow - 301 runs
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#32 - The dynamics of photosynthesis - variable sample size

by Jon Darkow - 24 runs
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The dynamics of photosynthesis - variable sample size

#33 - Stock, Inflow, and Outflow with Atrazine

by Jon Darkow - 7 runs
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Simple stock and flow diagram. Flows linear.

#34 - Carbon in the Atmosphere - Graphic Input constant

by Jon Darkow - 17 runs
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#35 - Grant Finches Mobile

by Jon Darkow - 2 runs
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#36 - Cardiovascular Model

by Jon Darkow - 0 runs
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#37 - Tryptophan Operon: A repressible system

by Jon Darkow - 18 runs
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