Irreversible Drug Effects - Proton Pump Inhibitors
Some drugs act by binding covalently to their receptors. As a result, the target is destroyed and it
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Some drugs act by binding covalently to their receptors. As a result, the target is destroyed and its function returns only when it has been replaced by newly synthesized product. The target may be a protein, DNA, an enzyme, or a cell at any stage of development. This model has been applied to the action of the proton pump inhibitors, which bind to and destroy the H+,K+-ATPase pumps in the parietal cells of the gastric mucosa. Normal proton secretion is restored only when the pumps are replaced by newly synthesized functioning pumps (i.e., the usual turnover time of the system).
Irreversible Drug Effects
Proton Pump Inhibitors
PPI Response Model