Matthias G. Wacker's Profile
Number of items: 5
Date joined: Aug 04 2019
Website: www.thewackerlab.com
Matthias G. Wacker is a pharmacometrician specializing in biopharmaceutics modeling. He and his team ...Read more Matthias G. Wacker is a pharmacometrician specializing in biopharmaceutics modeling. He and his team analyze patient data and develop novel computer models related to pharmacokinetics and biodistribution.
Matthias G. Wacker's Work
#1
Virtual Dissolution Lab
Dissolution testing is an important element in pharmaceutical quality control. The virtual dissoluti
... Read more
Dissolution testing is an important element in pharmaceutical quality control. The virtual dissolution lab illustrates the interplay between dissolution rate and bioavailability using the example of a bioequivalence study. Users can simulate a dissolution profile and the resulting pharmacokinetic profile. The model calculates the f1 and f2 value compared to a given reference product.
sim
⋮ 1330 runs
Science
pharma
#2
Pharmacokinetics and Bioavailability
sim
⋮ 473 runs
Science
#3
The Physiologically-based Nanocarrier Biopharmaceutics Model
The Physiologically-based Nanocarrier Biopharmaceutics (PBNB) model provides a simulation of the pro
... Read more
The Physiologically-based Nanocarrier Biopharmaceutics (PBNB) model provides a simulation of the processes involved in the pharmacokinetics of drug delivery systems such as liposomes, nanoparticles and micelles. It identifies the drug release and elimination of the carrier and the free drug alone and enables a prediction of important pharmacokinetic parameters such as the targeting capability and the mean residence time of the carrier in the blood plasma.
sim
⋮ 532 runs
Science
Education
nanomedicines
liposomes
PBPK
#4
Dialysis Membrane Permeation Calculator (DiMeC)
DIMEC can be used to calculate the membrane permeation rate from a permeation profile. The scientifi
... Read more
DIMEC can be used to calculate the membrane permeation rate from a permeation profile. The scientific applications include but are not limited to release testing of using various dosage forms.
sim
⋮ 127 runs
Science
dialysis
release
#5
Pharma Test Dispersion Release Normalizer (ReNo)
The PTDR is a release tester for pharmaceutical dosage forms and, in particular, for drug dispersion
... Read more
The PTDR is a release tester for pharmaceutical dosage forms and, in particular, for drug dispersions. The system uses dialysis to separate the dissolved drug from dosage form. Profile normalization is a deconvolution technique whereby the drug release profile is calculated from a data set reflecting the dialysis rate as well as the release profile.
sim
⋮ 141 runs
Science
release
ptdr
pharmaceutical
nanomedicines
Uploading a Bundle from Zip
Instead of creating bundles, categories, and assemblies one by one, you can upload a single zip file that contains all of your bundle's content. To create your zipped bundle, make a folder with your bundle's name and add subfolders with your categories' names. The folder tree should have the same structure that you want the categories to have in your bundle. Place your assembly .stmx files in the appropriate category folders, then zip your bundle folder and upload it using the Upload Bundle from Zip link above.
Assemblies, Bundles, and Categories
Assemblies are self contained models that demonstrate common ways to connect together building blocks and that can be used as parts of other models. This is analogous to using prefabricated wall and roof pieces to construct a house.
Bundles are groups of assemblies with a common use or theme. For example, a Health Care bundle might contain a variety of assemblies that aid in creating health care models. When you download assemblies from the isee Exchange™, you download an entire bundle, rather than individual assemblies.
Categories are subgroups of assemblies within a bundle. For example, a Health Care bundle might contain a Funding category for assemblies related to the management of hospital funds. All assemblies must be assigned to a category—they cannot be assigned to the root of a bundle.
Assemblies, bundles, and categories can be created and uploaded to the isee Exchange™ via the options on the Manage My Assemblies page. To learn more, visit our help pages, or take our assemblies tutorial.
Sim App (Sim)
An interface that allows users to interact with a model.
Sim apps allow users to interact with a model using buttons, sliders, knobs, tables, graphs, and storytelling. These interactions help users understand how parts of a system interact.
Interfaces are created by model authors in the Stella desktop software and can be uploaded to the isee Exchange™.
Model
A diagram that represents how elements in a system influence one another.
Models are mathematical representations of how elements in a system are connected and interact (e.g., ecosystems, organizations, supply chains). When running models on the isee Exchange™, results can be viewed in output devices like graphs and tables.
Models appear in the isee Exchange™ directory when authors upload them from the Stella® desktop software or create them with Stella Online™.
Causal Loop Diagram (CLD)
A map that represents the feedback structure of a system.
CLDs are high-level maps that represents the feedback structure of a system and easily communicate the essence of a model. They appear in the isee Exchange™ when authors upload them from the Stella desktop software or create them with Stella Online™.