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Number of items: 5
Date joined: Aug 04 2019

Matthias G. Wacker is a pharmacometrician specializing in biopharmaceutics modeling. He and his team ...Read more Matthias G. Wacker is a pharmacometrician specializing in biopharmaceutics modeling. He and his team analyze patient data and develop novel computer models related to pharmacokinetics and biodistribution. Hide full description


Matthias G. Wacker's Work

#1

Dialysis Membrane Permeation Calculator (DiMeC)

DIMEC can be used to calculate the membrane permeation rate from a permeation profile. The scientifi ... Read more
DIMEC can be used to calculate the membrane permeation rate from a permeation profile. The scientific applications include but are not limited to release testing of using various dosage forms.
sim75 runs
Science dialysis release
#2

Pharmacokinetics and Bioavailability

sim370 runs
Science
#3

Virtual Dissolution Lab

Dissolution testing is an important element in pharmaceutical quality control. The virtual dissoluti ... Read more
Dissolution testing is an important element in pharmaceutical quality control. The virtual dissolution lab illustrates the interplay between dissolution rate and bioavailability using the example of a bioequivalence study. Users can simulate a dissolution profile and the resulting pharmacokinetic profile. The model calculates the f1 and f2 value compared to a given reference product.
sim1118 runs
Science pharma
#4

The Physiologically-based Nanocarrier Biopharmaceutics Model

The Physiologically-based Nanocarrier Biopharmaceutics (PBNB) model provides a simulation of the pro ... Read more
The Physiologically-based Nanocarrier Biopharmaceutics (PBNB) model provides a simulation of the processes involved in the pharmacokinetics of drug delivery systems such as liposomes, nanoparticles and micelles. It identifies the drug release and elimination of the carrier and the free drug alone and enables a prediction of important pharmacokinetic parameters such as the targeting capability and the mean residence time of the carrier in the blood plasma.
sim357 runs
Science Education nanomedicines liposomes PBPK
#5

Pharma Test Dispersion Release Normalizer (ReNo)

The PTDR is a release tester for pharmaceutical dosage forms and, in particular, for drug dispersion ... Read more
The PTDR is a release tester for pharmaceutical dosage forms and, in particular, for drug dispersions. The system uses dialysis to separate the dissolved drug from dosage form. Profile normalization is a deconvolution technique whereby the drug release profile is calculated from a data set reflecting the dialysis rate as well as the release profile.
sim123 runs
Science release ptdr pharmaceutical nanomedicines
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Sim App (Sim)

An interface that allows users to interact with a model.

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Sim apps allow users to interact with a model using buttons, sliders, knobs, tables, graphs, and storytelling. These interactions help users understand how parts of a system interact.

Interfaces are created by model authors in the Stella desktop software and can be uploaded to the isee Exchange™.

Model

A diagram that represents how elements in a system influence one another.

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Models are mathematical representations of how elements in a system are connected and interact (e.g., ecosystems, organizations, supply chains). When running models on the isee Exchange™, results can be viewed in output devices like graphs and tables.

Models appear in the isee Exchange™ directory when authors upload them from the Stella® desktop software or create them with Stella Online™.

Causal Loop Diagram (CLD)

A map that represents the feedback structure of a system.

Image of a CLD

CLDs are high-level maps that represents the feedback structure of a system and easily communicate the essence of a model. They appear in the isee Exchange™ when authors upload them from the Stella desktop software or create them with Stella Online™.