Sara Rosenbaum's Work

We found 35 items

#1 - Pharmacokinetics: An IV Injection in a 1-Compartment Model

by Sara Rosenbaum - 3015 runs - 10 downloads
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#2 - Pharmacokinetics: An IV Injection on a Two Compartment Model

by Sara Rosenbaum - 1546 runs
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This model shows the profile of a drug after an intravenous injection when the drug displays two compartment characteristics

#3 - Oral Absorption

by Sara Rosenbaum - 2928 runs - 2 downloads
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This model is based on first order absoprtion in a 1-compartment model

#4 - Nonlinear Pharmacokinetics and Phenytoin

by Sara Rosenbaum - 1388 runs
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Nonlinear or capacity limited pharmacokinetics can occur whenever a process involved in the absorption, distribution or elimination of a drug becomes saturated. This model demonstrates nonlinear elimination (metabolism) using phenytoin as the model drug. Specifically, it demonstrates how increasing doses of the drug produce disproportionate increases in the plasma concentration. It also demonstrates how the model parameters, Km and Vmax influence of the plasma concentration -time profile.

#5 - Intravenous Infusion

by Sara Rosenbaum - 2082 runs
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This model demonstrates the pharmacokinetic characteristics of constant continuous drug administration.

#6 - Mulitple Bolus Injections Pharmacokinetics

by Sara Rosenbaum - 671 runs
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This model shows the typical plasma concentration profile associated with the administration of several doses of a drug over time. It demonstrates the determinants of the fluctuation in the plasma concentrations, the accumulation of the drug over the course of therapy and the resting steady state plasma concentrations.

#7 - Sigmoidal Emax Model of Drug Response

by Sara Rosenbaum - 343 runs - 10 downloads
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This is the model that is most commonly used to for the time course of drug effects in man. It assumes that the response is driven by the blood or plasma concentrations of the drug. When the model parameters are known, it can be used to predict response at anytime time after any dose.

#8 - Multiple Oral Doses Pharmacokinetics

by Sara Rosenbaum - 465 runs
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Most commonly people take oral doses of a drug over an extended period. This model demonstrates the unique plasma concentration profile associated with this type of drug administration. The model assumes first-order drug absorption with no lag time. Simulations can be carried out to observe how the rate and extent of absorption (bioavailability) affect the profile.

#9 - Irreversible Drug Effects - Proton Pump Inhibitors

by Sara Rosenbaum - 231 runs
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Some drugs act by binding covalently to their receptors. As a result, the target is destroyed and its function returns only when it has been replaced by newly synthesized product. The target may be a protein, DNA, an enzyme, or a cell at any stage of development. This model has been applied to the action of the proton pump inhibitors, which bind to and destroy the H+,K+-ATPase pumps in the parietal cells of the gastric mucosa. Normal proton secretion is restored only when the pumps are replaced by newly synthesized functioning pumps (i.e., the usual turnover time of the system).

#10 - Multiple Intermittent Infusions Pharmacokinetics

by Sara Rosenbaum - 290 runs
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The model shows the unique plasma concentration-time profile associated with the administration of a drug using multiple short infusions. It demonstrates the influence of the duration of the infusion and allows the user to practice the calculation of a suitable dose and dosing interval to achieve desired peak and trough plasma concentrations of a drug.

#11 - Indirect Effect Model 1

by Sara Rosenbaum - 256 runs
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Some drugs do not directly produce the measured drug response. Instead they act upstream, and either increase or decrease the amount of the entity that directly mediates the response (response variable). Indirect effect Model I can be used for drugs that inhibit the synthesis of the response variable. An example is warfarin which inhibits the synthesis of clotting factors.

#12 - Indirect Effect Model 3

by Sara Rosenbaum - 60 runs
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Some drugs do not directly produce the measured drug response. Instead they act upstream, and either increase or decrease the amount of the entity that directly mediates the response (response variable). Indirect effect Model III can be used for drugs that stimulate the production of the response variable. As a result they increase the amount of the response variable.

#13 - Transit Compartment of Drug Action

by Sara Rosenbaum - 92 runs
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Change image Submit your own comment on the simulation. Share Comment upgrade hosting plan delete simulation Transit Compartment Model of Drug Response By Sara Rosenbaum Sim URL: https://forio.com/simulate/sarar/transit-compartment-model Sim access:Other authors can download source model Sim plan: Simulate Free Sim stats:This sim has been run 326 times. This simulation was uploaded to Forio Simulate with the isee NetSim software. More information can be found at iseesystems.com. Your Rating: 1 star2 star3 star4 star5 star Average Rating: rating(1) Click here to edit the description A delay in response to a drug can occur when it takes a long time for the drug’s initial effect to be translated into the final response (a long transduction process). The delayed response profile can be captured using a series of transit compartments.

#14 - Indirect Effect Model 4

by Sara Rosenbaum - 21 runs - 2 downloads
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Some drugs do not directly produce the measured drug response. Instead they act upstream, and either increase or decrease the amount of the entity that directly mediates the response (response variable). Indirect effect Model IV can be used for drugs that stimulate the degradation of the response variable. As a result they decrease the amount of the response variable.

#15 - Model 21. Emax Model of Drug Response With an Effect Compartment

by Sara Rosenbaum - 174 runs - 4 downloads
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This model demonstrates how an effect compartment can be added to a pharmacokinetic model to accommodate a delay in drug response caused by a slow distribution of a drug to its site of action. The simulation also explains hysteresis

#16 - Tolerance- Precursor Pool Model

by Sara Rosenbaum - 140 runs
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Tolerance may be defined as a process that results in a reduction in the response to a specific drug concentration following repeated drug exposure. Tolerance could occur if an endogenous compound that plays an essential role in the response chain becomes depleted during response. This model assumes the drug stimulates the production of a response variable which becomes then becomes depleted.

#17 - Model 27. Hematological Toxicity of Anticancer Drugs

by Sara Rosenbaum - 120 runs
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This model shows the typical effect of several anticancer drugs on the number of circulating neutrophils. The drugs destroy neutrophils as they develop in the bone marrow, and its takes several days for their action to affect the circulating neutrophils. The model demonstrates how inter-individual variability in pharmacokinetics and pharmacodynamics can effect the magnitude and duration of this response.

#18 - Understanding Restrictive and Nonrestrictive Hepatic Clearance

by Sara Rosenbaum - 447 runs
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Many drugs are removed from the body by metabolism in the liver. A drug's hepatic clearance is a measure of the liver's ability to metabolize a drug. This simulation demonstrates the characteristics of high extraction (nonrestrictive clearance, low extraction (restrictive clearance and intermediate clearance.

#19 - Tolerance-Nicotine- Hypothetical Antagonist

by Sara Rosenbaum - 164 runs
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Tolerance may be defined as a process that results in a reduction in the response to a specific drug concentration following repeated drug exposure. One model for tolerance assumes that the drug produces a hypothetical metabolite that opposes its action.

#20 - Indirect Effect Model 2

by Sara Rosenbaum - 82 runs
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Some drugs do not directly produce the measured drug response. Instead they act upstream, and either increase or decrease the amount of the entity that directly mediates the response (response variable). Indirect effect Model 2 can be used for drugs that inhibit the degradation of the response variable. As a result they increase the amount of the response variable.

#21 - Model 2. Drug Transporters

by Sara Rosenbaum - 6625 runs
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This simulation shows the location and functioning of the major clinically important drug transporters in the : gastrointestinal membrane; renal tubular membrane; and the membranes of the hepatocyte. Simulations demonstrate their functioning after oral and intravenous doses of a drug substrate

#22 - Model 34. Fentanyl Induced Respiratory Depression and its Reversal With Naloxone

by Sara Rosenbaum - 187 runs
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This models demonstrates the varying degrees of respiratory depression caused by fentanyl and its reversal by naloxone. It also demonstrates that the action of naloxone is short lived and that additional doses may be needed

#23 - Model 20. DDI Drug-Drug Interactions - Pharmacodynamic

by Sara Rosenbaum - 19 runs
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This model demonstrates the interaction between two agonists. The pharmacodynamic characteristics of the perpetrator drug can be changed to create a full agonist, a partial agonist and a full antagonist

#24 - Model 17. DDI 5 Inhibition of Gut and Hepatic Metabolism

by Sara Rosenbaum - 8 runs
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This model demonstrates the effect of an inhibiotr that acts on enzymes both the gastrointestinal membrane and the liver. It also demonstrates the effect of grapefruit juice on drugs netaboliized by CYP3A

#25 - Take the Infusion Challenge

by Sara Rosenbaum - 268 runs
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Use this model to see if you can use a drug's pharmacokinetic and pharmacodynamic properties to determine the initial rate of drug administration. See if you can identify potential drug-drug interactions and respond when appropriate by making appropriate modifications to the dose.

#26 - Model 13. DDI 1 Time Dependent Enzyme Inhibition

by Sara Rosenbaum - 68 runs
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This simulation demonstrates the properties of time dependent enzyme inhibition. Specifically it shows how the inhibitor’s KI and kinact and the derived parameter kobs, control inhibition. It also demonstrates how the enzyme’s degradation rate constant controls recovery.

#27 - Model 20. DDI Drug-Drug Interactions - Pharmacodynamic

by Sara Rosenbaum - 3 downloads
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This model demonstrates the interaction between two agonists and allows the efficacy (Emax) of one to be varied

#28 - Integrated PK-PD Model For Lipoamide

by Sara Rosenbaum - 51 runs
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Lipoamide is a fictitious antipyretic (fever reducing) drug that is believed to work by reducing the synthesis of cytokines. Based on its mechanism of action and the characteristics of its response, an indirect effect model I (inhibition of kin) was used to model its effect. This model can be used to probe optimum dosing regimens of lipoamide.

#29 - Model 16. DDI 4 Time Dependent Enzyme Inhibition Desipramine and Paroxetine

by Sara Rosenbaum - 5 runs
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This simulation demonstrates the characteristics of time dependent enzyme inhibition using paroxetine's inhibition of desipramine as an example

#30 - Model 15. DDI 3 Reversisble Enzyme Inhibition: Midazolam Fluconazole

by Sara Rosenbaum - 10 runs
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This model demonstrates the characteristics of reversible enzyme inhibition using fluconazole's inhibition of midazolam as an example.

#31 - Extended Hepatic Cl Model

by Sara Rosenbaum - 6 runs
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This model assumes permeability controlled hepatic uptake and demonstrates the role of passive diffusion, hepatic uptake transporters, hepatic matabolism and hepatic efflux transporters on overall hepatic elimination

#32 - Model 14. DDI 2 Enzyme Induction

by Sara Rosenbaum - 9 runs
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This simulation demonstrates the model used for the induction of the drug metabolizing enzymes. It illustrates how the inducing drug's characteristics (Emax and EC50) control the degree of induction and the rate of degradation of the enzyme controls recove..

#33 - Physiologically Based Pharmacokinetic Model

by Sara Rosenbaum - 111 runs
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This model shows how to build a PBPK model and how drug concentrations in different tissues can be simulated

#34 - Model 1. Introduction to PK and PD

by Sara Rosenbaum - 584 runs
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This model allows users to use trial and error to identify appropriate doses of a drug for IV, oral and other extravascular routes of administration

#35 - Operational Model of Agonism

by Sara Rosenbaum - 279 runs
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The operational model of agonism provides a way of measuring drug efficacy and affinity in-vivo.