Directory

The isee Directory is home to a variety of simulations published by our customers. You can search to see what is there by specifying by Title, Description, Keywords or Author. The default page lists a selection that may be of interest.

You can also log in to manage your own simulations or use Stella Online to build models and CLD's.


We found 200 items

#1 - Lactase Enzyme Simulation with Data Analysis

by Jon Darkow - 81436 runs
Play

#2 - Photosynthesis Model

by Jon Darkow - 32704 runs
Play

#3 - Population dynamics of white footed mouse

by Jon Darkow - 14725 runs
Play

#4 - Cellular Respiration Accounting Model

by Jon Darkow - 6315 runs
Play

The purpose of the model is to understand how glucose is metabolized, and how the energy stored in its chemical bonds is transfered.

#5 - Apterous Genetics

by Jon Darkow - 6907 runs
Play

Apterous is an allele that results in a fly without wings. Wild-type variants have normally functioning wings. The goal of this simulation is to determine the pattern of inheritance for the apterous phenotype. Is apterous dominant or recessive? Sex-linked or autosomal? Complete, incomplete, or codominant?

#6 - Water Potential and Osmosis

by Jon Darkow - 3047 runs
Play

Factors that affect the flow across a semi-permeable membrane.

#7 - macrolab

by David Wheat - 2162 runs
Play

macrolab

#8 - Steady State in Freshwater Ecosystems

by Jon Darkow - 2360 runs
Play

#9 - White-Eyed Genetics

by Jon Darkow - 3188 runs
Play

White-eyed is an allele that results in a fly white eyes. Wild-type variants have red eyes. The goal of this simulation is to determine the pattern of inheritance for the white-eyed phenotype. Is yellow body dominant or recessive? Sex-linked or autosomal? Complete, incomplete, or codominant?

#10 - Growth Factors, Cyclins, and Cancer

by Jon Darkow - 11276 runs
Play

Explores the feedback loops that regulate the cell cycle. Model focuses on manipulating stimuli (growth factors), to stimulate the cell cycle feedback loops.

#11 - Evolution

by Jon Darkow - 1199 runs
Play

Evolution of Populations: Genetic Drift, Natural Selection, and Mutations

#12 - macrolab2016

by David Wheat - 1159 runs
Play

#13 - Extinction Vortex

by Jon Darkow - 1022 runs
Play

#14 - Evolution of LAP Allele in Mussels

by Jon Darkow - 2868 runs
Play

#15 - HPV and Adaptive Immune Response

by Jon Darkow - 993 runs
Play

#16 - Limits to Growth Archetype

by John Hayward - 590 runs - 17 downloads
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Shifting loop dominance in a limits-to-growth archetype is examined using the Hayward/Boswell Loop Impact Method.

#17 - Campus sexual assault

by Peter Hovmand - 547 runs - 11 downloads
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A very simple, one stock, simulation of campus sexist attitudes toward rape and initimate partner violence. The model was originally developed in 1998 and later translated into Stella. The model has a number of modeling errors, but at the time, proved useful for gaining insight into the dynamics of the system and developing an innovative prevention program.

#18 - Recombination and Gene Linkage

by Jon Darkow - 2110 runs
Play

#19 - The Laundry Detergent Game

by Billy Schoenberg - 259 runs - 15 downloads
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Congratulations! You've just been hired by the major grocery chain The Price Shopper as head of marketing. Your job is to turn around The Price Shopper's dismal sales of laundry detergent. The big-wigs have given you 12 months and a marketing budget of up to $10,000 per month to spend as you please. They'll decide to keep you, or send you to the cleaners based on how much profit you bring in over the year. Do you think you can make the big MONEY?

#20 - mse-litsim

by Lorenzo Andrade - 591 runs
Play

Modelo de Simulación de Escenarios MSE-LITSIM

#21 - Zombie Apocalypse

by isee systems - 721 runs
Play

This is our first model in the From Imagination to Simulation series. It is a nod to the Halloween season and investigates a zombie apocalypse! Our fascination with zombies continually grows with the help of movies, TV shows, and books that give a wide range of zombie possibilities. But what are the dynamics behind a zombie epidemic? This model will specifically look at the spread of a zombie outbreak and examine some of the variables that help and hinder the rate of infection. We hope you will continue to see the benefits and versatility of Systems Thinking and enjoy our new series, From Imagination to Simulation! Continue to ponder those out-of-the-ordinary problems. They may seem unrealistic, but perhaps some of their dynamics may resonate with reality. Check out our zombie apocalypse model to see if there is any chance for human survival!

#22 - Transformation Simulation

by Jon Darkow - 991 runs
Play

Simulation allows students to test the transformation principle. Two major goals of the experiment are: 1. Allow users to see that supernatant from heat-killed bacteria can transform the genes of another bacterium. 2. What transforms the inheritance of the bacteria is DNA, not RNA or proteins.

#23 - Salmon Simulator

by James Pratt - 460 runs
Play

Simulation of salmon populations with harvesting using the Tucannon River (WA) as an example. Simulation accompanies the text Modeling the Environment, 2nd ed. by Andrew Ford. Used with permission.

#24 - Le budget de la ville de Quimper

by Valerie Gacogne - 592 runs
Play

#25 - Vacation

by isee systems - 394 runs
Play

Do you ever feel like work is taking over your life? Burnout is generally characterized as a state of mental and physical exhaustion resulting in low productivity and de-personalization and is most likely caused by prolonged stress that does not dissipate. There are many different aspects that affect both the building and dissipation of burnout. This model focuses on workloads and vacations to see how they contribute to both your level of burnout and productivity. Use this model to ask questions about your workload and any benefits you would receive from taking a vacation. What happens when you suddenly have a bigger workload? What happens when work piles up? Does vacation increase or decrease your stress levels?

#26 - Weight Loss Sim

by Corne - 476 runs
Play

This simulation gives the user the ability to specify their own current condition (weight, age, height etc.), choose their exercise regime and eating plans. The simulator then gives a projection for the user's weight for the next year (at a weekly resolution). Please take note that most of the pictures are navigation buttons to different screens, so remember to click on the pictures. I have personally used this simulator to successfully lose more than 20 kg. Hope you find this as valuable as I did. Good luck with your weight journey!

#27 - Feebates

by James Pratt - 508 runs
Play

Model of fees and rebates for air pollution control based on differing vehicle types. Model orginally developed by Andrew Ford to accompany Modeling the Environment, 2nd Ed., Island Press (2010) . Used with permission.

#28 - PCU-curso-VSN

by Armando Izquierdo - 223 runs
Play

Este modelo es un primer intento de utilizar el "Business Canvas" desarrollado por Alexander Osterwalder e Yves Pigneur, para explicar su carácter sistémico mediante la simulación de un modelo de negocio genérico utilizando Stella Architect. El objetivo principal es mostrar el vínculo entre los conceptos del pensamiento sistémico y la práctica del "Systems Dynamics" con el ampliamente difundido "Business Canvas". En la narrativa utilizada para describir la construcción del diagrama "Stock & Flow", se denomina entre parentesis el tipo de componente (Stock, Flow, Converter, o Conector) correspondiente a los principales elementos del modelo de negocio. La simulación permite visualizar la naturaleza sistémica de un modelo de negocio representado mediante el "Business Canvas".

#29 - Phenology of the Karner Blue Butterfly

by Jon Darkow - 220 runs
Play

Karner Blue butterfly is an endangered species. Habitat loss and climate change are contributing factors to the reduction in the butterflies' population sizes. Climate change can alter the timing of lifecycles. When climate change disproportionally affects the timing of life cycles of species in an ecosystem asynchrony within a food web occurs.

#30 - Turchin’s Metaethnic Frontier Theory of Imperial Growth

by John Hayward - 59 runs - 11 downloads
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A country builds its empire by attacking its neighbours and taking over both their land and their people. The larger the empire becomes, the more resources they have available to take further territory by force. However the further they expand, the harder they find it to keep expanding due to the geographical and organisational logistics involved. Additionally the empire finds it harder to maintain social cooperation among its people, its asabiya.

#31 - Inventory Workforce Model

by John Hayward - 176 runs - 25 downloads
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Oscillations in an Inventory Workforce model are examined using the Hayward/Boswell Loop Impact Method.

#33 - Product Development Simulator

by Billy Schoenberg - 283 runs
Play

The Bass Model or Bass Diffusion Model was developed by Frank Bass and it consists of a simple differential equation that describes the process of how new products get adopted in a population. The model presents a rationale of how current adopters and potential adopters of a new product interact.

#34 - College Loans

by isee systems - 142 runs
Play

Each year, the cost of a college education continues to rise and more and more students must turn to student loans to complete their education. But as graduates leave college to embark on their careers, they face an almost Sisyphean struggle with student debt, forever facing an uphill battle while carrying a heavy burden, only to find they are getting nowhere! Whether you are graduating from college or just entering, we hope this model will enable you to better understand student loans and help plan for your future.

#35 - MNH Strategic Model

by Peter Hovmand - 554 runs
Play

Strategic model of country-level policies to reduce maternal and neonatal mortality.

#36 - Supply and demand model

by Yaroslav Vorobiov - 173 runs - 25 downloads
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Supply and demand model

#37 - DaisyWorld

by James Pratt - 320 runs
Play

Game model of Daisyworld. Model orginally developed by Andrew Ford to accompany Modeling the Environment, 2nd Ed., Island Press (2010) . Used with permission.

#38 - SDGs Interactions, v2

by Dave Zelinka - 188 runs - 1 download
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This simulation analyzes the interactions among the six Sustainable Development Goals (SDGs) that are the focus of the Second Annual Multi-stakeholder Forum on Science, Technology, and Innovation for the Sustainable Development Goals (STI Forum).

#39 - WELFCNexus Anthroposphere Framework, v0.4

by Dave Zelinka - 3 runs - 6 downloads
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Here we depict a melding of two systems of thought: the water-energy-land-food-climate (WELFC) nexus with the Anthroposphere. It analyzes the complex interactions among the WELFC sectors within the global context of the human sphere, containing the political, economic, social, environmental, etc. to form a holistic framework to understand how all these sector function together.

#40 - Limited Enthusiasm Model of Church Growth

by John Hayward - 113 runs - 7 downloads
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A model of the growth of the Christian Church in periods of religious revival. The growth mechanism is similar to the spread of an infectious disease.

#41 - zFourth Position - don't move

by Automated Tests - 456 runs
Play

#42 - General Practice Advanced skill simulator

by Whole Systems Partnership - 213 runs
Play

A model to explore changing roles within the advanced skilled workforce for General Practice in the UK.

#43 - Emergency Room

by Billy Schoenberg - 137 runs
Play

This simulation shows the basic dynamics of a hospital emergency room. Patients arrive, are treated and leave. You are able to control the average arrivial rate and average treatment time. This simulation was made using the 3rd party developer API embedded within Stella Architect.

#44 - Collins Theory of Geopolitics - Effect of War

by John Hayward - 140 runs - 7 downloads
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The spread of an empire according to the theory of Randall Collins and equations of Peter Turchin

#45 - Health Policy Management Flight Simulator

by Shamim - 973 runs
Play

This is a basic health policy simulator that allows the user a policy lever on where to prioritise health care spending.

#46 - Salmon Hypoxia Modeling Lab

by Ryan Bellmore - 257 runs
Play

This model simulates the influence of spawning salmon on dissolved oxygen in southeast Alaskan Rivers.

#47 - Human Ecological Systems (HES)

by Peter Hovmand - 86 runs
Play

The purpose of this model is to (1) demonstrate a way to represent human development that includes individual resources, social networks, and spatial relationships within a single model of a formal feedback theory of development, (2) provide an approach to theory development that begins with a simple model and gradually includes more complex facets of social reality (e.g., social networks, location), and (3) illustrate its application to formally testing and comparing a theory over a wider range of assumptions that can inform the design of data collection and analysis to more accurately reflect the dynamics of human development and outcomes. The approach has a wide range of possible applications in theory development and community intervention design, research, and evaluation. Examples include school-based and community based positive youth development interventions, drug use/addiction and treatment in rural settings, community responses to domestic violence, neighborhood effects and interventions, homelessness, supports for ex-offenders released from prison or jail, and health inequities. Version 1.0 focuses on mainly working out a simple example of interactions between social networks and spatial relationships. The model (right) represents a formal theory of how people will move to be close to their nearest friend. Since friends are determined by a social network where people have different sets of friends, and people are in different locations, movement will depend on an interaction between each individual’s social network, the location of their friends, the distance to their friends, and identifying their nearest friend and comparing one’s present location to the location of one’s nearest friend. The model implements this with a random social network for 100 individuals randomly distributed in 100m by 100m coordinate space.

#48 - Headcount Strategy

by isee systems - 39 runs
Play

Explore a consulting firm’s headcount strategy. Understand the relationship between growth rates, promotion times, headcount pyramid ratios, and attrition rates. This model is based on actual work that was done with a very well-known consulting company (here, code-named TWBC, Inc.). The firm's strategic goals were well-articulated, and each made sense when written down in a list on a piece of paper. However, when subjected to the more rigorous, dynamic scrutiny that an iThink modeling effort provides, the goals (as is too often the case) turned out to be in conflict with one another--stimulating actions that worked at cross-purposes. Efforts to achieve one goal drove the firm farther away from achieving the others. The subsequent analysis conducted with the model also pointed the way toward resolving the internal strategic inconsistencies and putting the firm back onto a strategically sound growth path.

#49 - Trp Operon

by Jon Darkow - 1169 runs
Play

Tryptophan is an amino acid that is synthesized by plants and bacteria from other molecules in a biochemical pathway (see diagram below). The trypophan operon is a series of sequential genes found on a bacterial genome. The genes of the operon produce the enzymes that direct the synthesis of tryptophan. In this model you will experiment with the negative feedback loop of the repressible system.

#50 - Dynamic Modelling of Lionfish Invasion in the Caribbean Sea and Atlantic Ocean

by Gian Wieck - 92 runs
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The dynamic model shall explain the rapid diffusion of the lionfish - an invasive species - throughout the Caribbean Sea and the Atlantic Ocean. The interface contains two explanatory models - a simple diffusion model and more realistic convection model - as well as a policy game to manage the regional countermeasures of local decision makers.

#51 - Collins Theory of Geopolitics - Logistical Load

by John Hayward - 31 runs - 8 downloads
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The spread of an empire according to the theory of Randall Collins and equations of Peter Turchin. Includes limits to growth due the distance beween the empire's expansion zone and centre.

#52 - Dynaville

by Valerie Gacogne - 118 runs
Play

Dynaville simule l'évolution des habitants d'un territoire à un horizon de 10 ans (ménages, déplacements...), selon différents scénarios de logements, d'emplois et d'évolution de son attractivité.

#53 - Neurophysiology and Neurotoxicity

by Jon Darkow - 24 runs
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The main dependent variable measured in the model is the membrane potential (millivolts) of a motor neuron and the muscle fiber it innervates. You will be able to add excitatory and inhibitory neurotransmitters, and compare how neurotransmitters modulate the electrical impulses of the motor neuron and the muscle fiber. Additionally, you will be able to compare the effects of four neurotoxins: Tetrodotoxin, botulinum toxin, sarin nerve gas, and VX. While extremely lethal, these toxins are very instructive in understanding neurons because of the specific way the toxins act. Each toxin modifies or inhibits a specific molecule in neurons that help process and transmit information.

#54 - Understanding Restrictive and Nonrestrictive Hepatic Clearance

by Sara Rosenbaum - 69 runs
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Many drugs are removed from the body by metabolism in the liver. A drug's hepatic clearance is a measure of the liver's ability to metabolize a drug. This simulation demonstrates the characteristics of high extraction (nonrestrictive clearance, low extraction (restrictive clearance and intermediate clearance.

#55 - Urban Business Expansion

by John Hayward - 54 runs - 9 downloads
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The business sector of the Three Stock Urban Dynamics model is examined using the Hayward/Boswell Loop Impact Method.

#56 - Humanitarian Aid

by isee systems - 53 runs
Play

A look at disaster relief under uncertain local government scenarios. It looks at how long it might take to establish clean water thru flying in bottled water and constructing wells. There is also the impact on spread of disease and survival due to lack of water. Created by Mark Heffernan and George McDonnel

#57 - Urban Stream Rainfall

by Samuel Austin - 203 runs
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A simple example of streamflow response to rainfall and basin percent urban area.

#58 - Model 2. Drug Transporters

by Sara Rosenbaum - 141 runs
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This simulation shows the location and functioning of the major clinically important drug transporters in the : gastrointestinal membrane; renal tubular membrane; and the membranes of the hepatocyte. Simulations demonstrate their functioning after oral and intravenous doses of a drug substrate

#59 - FIT Success or Failure

by FIT Success or Failure - 152 runs
Play

Three key events that affect a young military members financial well being

#60 - Lactose Operon: An Inducible System

by Jon Darkow - 5482 runs
Play

In this simulation users explore the negative feedback system of the Lactose Operon found in bacteria. Lactose induces the system by inhibiting and inhibitor.

#61 - Information Processing and Neurophysiology Model

by Jon Darkow - 16068 runs
Play

The main dependent variable measured in the model is the membrane potential (millivolts) of two different neurons in a series. You will be able to add excitatory and inhibitory neurotransmitters, and compare how these modulate electrical impulses of the two neurons. Additionally, you will be able to compare the effects of three neurotoxins: Tetrodotoxin, botulinum toxin, and sarin nerve gas. While extremely lethal, these toxins are very instructive in understanding neurons because of the specific way the toxins act. Each toxin modifies or inhibits a specific molecule in neurons that help process and transmit information.

#62 - The Dynastic Cycle

by John Hayward - 107 runs - 6 downloads
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The model of Feichtinger, Forst and Piccardi.

#63 - Nonlinear Pharmacokinetics and Phenytoin

by Sara Rosenbaum - 42 runs
Play

Nonlinear or capacity limited pharmacokinetics can occur whenever a process involved in the absorption, distribution or elimination of a drug becomes saturated. This model demonstrates nonlinear elimination (metabolism) using phenytoin as the model drug. Specifically, it demonstrates how increasing doses of the drug produce disproportionate increases in the plasma concentration. It also demonstrates how the model parameters, Km and Vmax influence of the plasma concentration -time profile.

#64 - Educational Outcomes

by Emily Brzozowski - 56 downloads
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Educational outcomes in relation to resource allocation

#65 - Model 34. Fentanyl Induced Respiratory Depression and its Reversal With Naloxone

by Sara Rosenbaum - 118 runs
Play

This models demonstrates the varying degrees of respiratory depression caused by fentanyl and its reversal by naloxone. It also demonstrates that the action of naloxone is short lived and that additional doses may be needed

#66 - Irreversible Drug Effects - Proton Pump Inhibitors

by Sara Rosenbaum - 47 runs
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Some drugs act by binding covalently to their receptors. As a result, the target is destroyed and its function returns only when it has been replaced by newly synthesized product. The target may be a protein, DNA, an enzyme, or a cell at any stage of development. This model has been applied to the action of the proton pump inhibitors, which bind to and destroy the H+,K+-ATPase pumps in the parietal cells of the gastric mucosa. Normal proton secretion is restored only when the pumps are replaced by newly synthesized functioning pumps (i.e., the usual turnover time of the system).

#67 - Spread of Disease

by John Hayward - 29 runs - 13 downloads
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A simple SIR model is examined using the Hayward/Boswell Loop Impact Method.

#68 - Leg VS Asprin

by Abbey McDonald - 15 downloads
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#69 - Anima el PIB mundial

by Martin Schaffernicht - 26 downloads
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Animación del PIB mundial de los últimos 25 años, para mis estudiantes de Economía (IIE/FEN/UTALCA)

#70 - my new model

by Lavigne - 24 downloads
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This model was copied from Emily Brzozowski: Educational outcomes in relation to resource allocation

#71 - simpleMP

by David Wheat - 347 runs
Play

#72 - Mammoth Game

by Johanna Lockhart - 5 downloads
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Extinction of Mammoths

#73 - Indirect Effect Model 4

by Sara Rosenbaum - 4 runs
Play

Some drugs do not directly produce the measured drug response. Instead they act upstream, and either increase or decrease the amount of the entity that directly mediates the response (response variable). Indirect effect Model IV can be used for drugs that stimulate the degradation of the response variable. As a result they decrease the amount of the response variable.

#74 - Indirect Effect Model 3

by Sara Rosenbaum - 25 runs
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Some drugs do not directly produce the measured drug response. Instead they act upstream, and either increase or decrease the amount of the entity that directly mediates the response (response variable). Indirect effect Model III can be used for drugs that stimulate the production of the response variable. As a result they increase the amount of the response variable.

#75 - Consumo de agua

by esteban - 20 downloads
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Este modelo es sobre cuanto nos demoramos en la ducha y cuanto estamos gastando por dia.

#76 - Multiple Oral Doses Pharmacokinetics

by Sara Rosenbaum - 38 runs
Play

Most commonly people take oral doses of a drug over an extended period. This model demonstrates the unique plasma concentration profile associated with this type of drug administration. The model assumes first-order drug absorption with no lag time. Simulations can be carried out to observe how the rate and extent of absorption (bioavailability) affect the profile.

#77 - Urbanseed light demo

by Valerie Gacogne - 127 runs
Play

Cette version légère de démonstration d'Urbanseed s'applique à l'aménagement de nouveaux quartiers. Combien d'habitants une emprise peut-elle accueillir? Quels équipements scolaires prévoir?

#78 - Multiple Intermittent Infusions Pharmacokinetics

by Sara Rosenbaum - 5 runs
Play

The model shows the unique plasma concentration-time profile associated with the administration of a drug using multiple short infusions. It demonstrates the influence of the duration of the infusion and allows the user to practice the calculation of a suitable dose and dosing interval to achieve desired peak and trough plasma concentrations of a drug.

#79 - Lav kraftforpris

by Culti Visus - 43 downloads
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lav kraftforpris

#80 - Abastecimento de Água

by Mariana Lago - 63 downloads
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Demanda de água gera novos investimentos em infraestrutura de abastecimento

#81 - Medical Resident VS Patients

by Abbey McDonald - 12 downloads
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Who will win? The not yet doctor, or the street duo who needs medicine but in a controlled fashion? Who will go home in this TITLE FIGHT? Who will stay in the hospital

#82 - Factors affecting the rate of evaporation of water

by Anne Wong - 55 downloads
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To investigate how rate of evaporation of water is affected by different factors

#83 - A Simple Example of System Dynamics Modeling

by Saeed Langarudi - 59 runs
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This is a simple, working example of system dynamics model which was used as a supporting material in my seminar in "What is System Dynamics?" on Feb 24th at Water Resources Research Institute, New Mexico State University.

#84 - Mulitple Bolus Injections Pharmacokinetics

by Sara Rosenbaum - 60 runs
Play

This model shows the typical plasma concentration profile associated with the administration of several doses of a drug over time. It demonstrates the determinants of the fluctuation in the plasma concentrations, the accumulation of the drug over the course of therapy and the resting steady state plasma concentrations.

#85 - Rise and Fall of Empires

by John Hayward - 7 runs
Play

Empires rise through the desire for things such as power, peace & wealth. It can even attract others. However the rise of nationalism, institutionalism and the remoteness of the ruling elite can lead to imperial decline

#86 - Modelo intro fondo de pensiones

by Martin Schaffernicht - 11 downloads
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Modelo con la estructura básica de un fondo de pensiones

#87 - Put Trust In Your Models

by Whole Systems Partnership - 32 runs
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Putting trust in your model is a simple demonstration of the importance of the human dimension to system change. By thinking about trust as something that impacts on human behaviours this model shows how investment in such factors can be better for the patient and for finances.

#88 - Model 20. DDI Drug-Drug Interactions - Pharmacodynamic

by Sara Rosenbaum - 8 runs
Play

This model demonstrates the interaction between two agonists. The pharmacodynamic characteristics of the perpetrator drug can be changed to create a full agonist, a partial agonist and a full antagonist

#89 - Model 17. DDI 5 Inhibition of Gut and Hepatic Metabolism

by Sara Rosenbaum - 3 runs
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This model demonstrates the effect of an inhibiotr that acts on enzymes both the gastrointestinal membrane and the liver. It also demonstrates the effect of grapefruit juice on drugs netaboliized by CYP3A

#90 - Urgent Care Hub Workforce Simulator

by Whole Systems Partnership - 106 runs
Play

#91 - Model 27. Hematological Toxicity of Anticancer Drugs

by Sara Rosenbaum - 12 runs
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This model shows the typical effect of several anticancer drugs on the number of circulating neutrophils. The drugs destroy neutrophils as they develop in the bone marrow, and its takes several days for their action to affect the circulating neutrophils. The model demonstrates how inter-individual variability in pharmacokinetics and pharmacodynamics can effect the magnitude and duration of this response.

#92 - STELLA water model

by Armelita - 26 downloads
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#93 - Transit Compartment of Drug Action

by Sara Rosenbaum - 50 runs
Play

Change image Submit your own comment on the simulation. Share Comment upgrade hosting plan delete simulation Transit Compartment Model of Drug Response By Sara Rosenbaum Sim URL: https://forio.com/simulate/sarar/transit-compartment-model Sim access:Other authors can download source model Sim plan: Simulate Free Sim stats:This sim has been run 326 times. This simulation was uploaded to Forio Simulate with the isee NetSim software. More information can be found at iseesystems.com. Your Rating: 1 star2 star3 star4 star5 star Average Rating: rating(1) Click here to edit the description A delay in response to a drug can occur when it takes a long time for the drug’s initial effect to be translated into the final response (a long transduction process). The delayed response profile can be captured using a series of transit compartments.

#94 - The Console Wars

by Maximilian Happach - 7 runs
Play

This is the first interface I built. It is the result of a one week seminar on Stella Architect taught by Billy Schoenberg in Bergen in 2016. We spent 2 days on an introduction into Stella Architect.

#95 - Land-Use Change, v0.1

by Dave Zelinka - 29 downloads
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#96 - Tolerance- Precursor Pool Model

by Sara Rosenbaum - 10 runs
Play

Tolerance may be defined as a process that results in a reduction in the response to a specific drug concentration following repeated drug exposure. Tolerance could occur if an endogenous compound that plays an essential role in the response chain becomes depleted during response. This model assumes the drug stimulates the production of a response variable which becomes then becomes depleted.

#97 - Rocket Model

by Christopher DiCarlo - 60 downloads
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Rocket Model with Wind Resistance

#98 - Sigmoidal Emax Model of Drug Response

by Sara Rosenbaum - 116 runs
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This is the model that is most commonly used to for the time course of drug effects in man. It assumes that the response is driven by the blood or plasma concentrations of the drug. When the model parameters are known, it can be used to predict response at anytime time after any dose.

#99 - Evolution and Natural Selection

by Jon Darkow - 7088 runs
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#100 - Take the Infusion Challenge

by Sara Rosenbaum - 12 runs
Play

Use this model to see if you can use a drug's pharmacokinetic and pharmacodynamic properties to determine the initial rate of drug administration. See if you can identify potential drug-drug interactions and respond when appropriate by making appropriate modifications to the dose.

#101 - Land-Use Construction, v0.1

by Dave Zelinka - 19 downloads
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#102 - Overshoot and Collapse

by John Hayward - 8 runs - 6 downloads
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Overshoot and collapse behaviour is examined using the Hayward/Boswell Loop Impact Method.

#103 - Indirect Effect Model 1

by Sara Rosenbaum - 12 runs
Play

Some drugs do not directly produce the measured drug response. Instead they act upstream, and either increase or decrease the amount of the entity that directly mediates the response (response variable). Indirect effect Model I can be used for drugs that inhibit the synthesis of the response variable. An example is warfarin which inhibits the synthesis of clotting factors.

#104 - Urbanization, v0.1

by Dave Zelinka - 17 downloads
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#105 - Model 13. DDI 1 Time Dependent Enzyme Inhibition

by Sara Rosenbaum - 53 runs
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This simulation demonstrates the properties of time dependent enzyme inhibition. Specifically it shows how the inhibitor’s KI and kinact and the derived parameter kobs, control inhibition. It also demonstrates how the enzyme’s degradation rate constant controls recovery.

#106 - pescarbc

by Lorenzo Andrade - 88 runs
Play

Este es un modelo demostrativo de simulación de escenarios en que es posible indagar como se puede compatibilizar tanto la sustentabilidad del recurso pesquero como la maximización de los beneficios económicos por parte de los pescadores.

#107 - Population-resource

by Anne LaVigne - 85 runs - 9 downloads
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A basic population/resource model

#108 - Indirect Effect Model 2

by Sara Rosenbaum - 4 runs
Play

Some drugs do not directly produce the measured drug response. Instead they act upstream, and either increase or decrease the amount of the entity that directly mediates the response (response variable). Indirect effect Model 2 can be used for drugs that inhibit the degradation of the response variable. As a result they increase the amount of the response variable.

#109 - Sediment Motion In Streams And Rivers

by Samuel Austin - 45 runs
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An illustration of bed sediment motion in streams and rivers using equations developed by Shields and Strickler.

#110 - Estimating Fluid Flow Using Darcys Law

by Samuel Austin - 45 runs
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A simple model using Darcy's law to estimate fluid flow through porous material over a fixed distance.

#111 - EPIDEMRES

by Serge Savary - 13 runs - 1 download
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EPIDEMRES is a generic epidemiological model which simulates plant disease epidemic development over time and accounts for host growth and accounts for quantitative host plant resistance

#112 - Integrated PK-PD Model For Lipoamide

by Sara Rosenbaum - 10 runs
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Lipoamide is a fictitious antipyretic (fever reducing) drug that is believed to work by reducing the synthesis of cytokines. Based on its mechanism of action and the characteristics of its response, an indirect effect model I (inhibition of kin) was used to model its effect. This model can be used to probe optimum dosing regimens of lipoamide.

#113 - Model 16. DDI 4 Time Dependent Enzyme Inhibition Desipramine and Paroxetine

by Sara Rosenbaum - 3 runs
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This simulation demonstrates the characteristics of time dependent enzyme inhibition using paroxetine's inhibition of desipramine as an example

#114 - d

by Dawoon113 - 11 downloads
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This model was copied from Christopher DiCarlo: Rocket Model with Wind Resistance

#115 - Two Capacities (updated)

by Douglas McKelvie - 111 runs
Play

This model is mainly for me to experiment with the new Stella Architect software but by all means have a play. More detail to be added.

#116 - Fatigue_at_work

by Victor Celestino - 35 downloads
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Meta model of fatigue at work

#117 - Model 21. Emax Model of Drug Response With an Effect Compartment

by Sara Rosenbaum - 36 runs
Play

This model demonstrates how an effect compartment can be added to a pharmacokinetic model to accommodate a delay in drug response caused by a slow distribution of a drug to its site of action. The simulation also explains hysteresis

#118 - SCM

by Bernardo Paixao - 42 downloads
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Solar Cooker

#119 - Model 15. DDI 3 Reversisble Enzyme Inhibition: Midazolam Fluconazole

by Sara Rosenbaum - 3 runs
Play

This model demonstrates the characteristics of reversible enzyme inhibition using fluconazole's inhibition of midazolam as an example.

#120 - Caribou Road Crossing Behaviour

by Rob Rempel - 157 runs
Download Model Play

Simulation of factors affecting fear of crossing and risk of death due to roads

#121 - Agua virtudes

by Laura - 29 downloads
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Gasto de egua en 10 dias

#122 - interface-tutorial-start

by documentation - 138 downloads
Download Model

Starting model for interface building tutorial.

#123 - Intravenous Infusion

by Sara Rosenbaum - 43 runs
Play

This model demonstrates the pharmacokinetic characteristics of constant continuous drug administration.

#124 - SCM

by Oliver Cox - 35 downloads
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Solar Cooker

#125 - WHEATPEST

by Laetitia Willocquet - 12 runs
Download Model Play

WHEATPEST is an agrophysiological model for wheat which simulates the effects of diseases and pests on crop growth and yield, through damage mechanisms.

#126 - RICEPEST

by Laetitia Willocquet - 48 runs
Download Model Play

RICEPEST is an agrophysiological model for rice which simulates the effects of diseases and pests on crop growth and yield, through damage mechanisms.

#127 - Modelo 2

by Christian Geraldino - 39 downloads
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<?xml version="1.0" encoding="utf-8" ?> <xmile version="1.0" level="3" xmlns="http://www.systemdynamics.org/XMILE" xmlns:isee="http://iseesystems.com/XMILE"> <header> <smile version="1.0" namespace="std isee" /> <name>Modelo 2 Clase Simulacion</name> <uuid>57f2513d-2e6e-40c3-ab65-20504b309974</uuid> <vendor>isee systems inc.</vendor> <product version="10.0.6" lang="en">iThink</product> </header> <style> <model font-family="Arial" font-size="9" /> <interface font-family="Arial" font-size="9" /> </style> <sim_specs method="Euler" time_units="Days"> <start>1</start> <stop>37</stop> <dt>1</dt> </sim_specs> <model_units /> <isee:prefs layer="model" grid_width="20" grid_height="50" divide_by_zero_alert="true" hide_taskbar="true" show_module_prefix="true"> <isee:window width="1350" height="669" /> <isee:security /> <isee:print_setup width="612" height="792" /> </isee:prefs> <isee:equation_prefs order_by="module" /> <model> <stock name="monto"> <doc>800000</doc> <eqn>800000</eqn> <outflow>INTERESES</outflow> <display x="82" y="116" color="blue" /> </stock> <flow name="INTERESES"> <eqn>monto*TASA_DIARIA_ANTICIPADA</eqn> <non_negative /> <display x="180" y="115" color="blue"> <pts> <pt x="104" y="115" /> <pt x="256" y="115" /> </pts> </display> </flow> <aux name="TASA_DIARIA_ANTICIPADA"> <eqn>+(TASA_DIARIA_VENCIDA)/(1+TASA_DIARIA_VENCIDA)</eqn> <display x="198" y="231" color="blue" label_side="right" label_angle="322" /> </aux> <aux name="TASA_DIARIA_VENCIDA"> <eqn>+((1+0.32)^(1/360))-1</eqn> <display x="102" y="255" color="blue" /> </aux> <display page_width="612" page_height="792" isee:converter_size="medium" isee:animate_flows="true" isee:animate_stocks="true" isee:animate_converters="true" report_balances="ending" report_flows="summed"> <connector x="104" y="99" uid="0" color="#FF007F"> <from>monto</from> <to>INTERESES</to> </connector> <connector x="111" y="256" uid="1" color="#FF007F"> <from>TASA_DIARIA_VENCIDA</from> <to>TASA_DIARIA_ANTICIPADA</to> </connector> <connector x="206" y="227" uid="2" color="#FF007F"> <from>TASA_DIARIA_ANTICIPADA</from> <to>INTERESES</to> </connector> <stacked_container height="282" width="492" uid="3"> <graph type="time_series" background="#FFFFC9" show_grid="true" plot_numbers="true" isee:use_five_segments="false" date_time="2017-01-27T21:20:02Z" time_precision="2" from="1" to="37"> <title>Untitled</title> <plot index="0" pen_width="1" color="blue" precision="1" show_y_axis="true"> <entity name="monto" /> </plot> </graph> </stacked_container> <pad_icon x="437" y="422" width="26" height="22" color="#008F44" label_side="bottom" label="Graph 1" type="graph" icon_of="3" /> <stacked_container height="270" width="475" uid="4"> <table font-size="9" background="#E0E0E0" columns_width="59" column_width="59" orientation="vertical" report_balances="ending" report_flows="summed" date_time="2017-01-27T21:20:02Z"> <title>Untitled Table</title> <item type="time" color="black" precision="max" width="100" /> <item color="black" precision="0.01" delimit_000s="true" index="0"> <entity name="monto" /> </item> <item color="black" precision="max" delimit_000s="true" index="1"> <entity name="INTERESES" /> </item> <item color="black" precision="max" delimit_000s="true" index="2"> <entity name="TASA_DIARIA_ANTICIPADA" /> </item> </table> </stacked_container> <pad_icon x="81" y="386" width="26" height="22" color="#008F44" label_side="bottom" label="Table 1" type="table" icon_of="4" /> <text_box x="5" y="3" uid="5" color="black" font-family="Arial" font-size="12" padding="5" border-style="solid" border-width="thin" width="260" height="58">CUAL ES EL VALOR PRESENTE DE $ 800.000 EN 36 DIAS AL 32% EA EN UN AÑO DE 360 DIAS</text_box> <numeric_display precision="0.01" delimit_000s="true" color="blue" show_name="true" retain_ending_value="true" uid="6" x="77" y="325"> <entity name="monto" /> </numeric_display> </display> <interface page_width="788" page_height="528"> <simulation_delay>0.1</simulation_delay> </interface> <popup x="291" y="381" visible="true" content="3" /> <popup x="30" y="442" visible="true" content="4" /> </model> </xmile>

#128 - Extended Hepatic Cl Model

by Sara Rosenbaum - 3 runs
Play

This model assumes permeability controlled hepatic uptake and demonstrates the role of passive diffusion, hepatic uptake transporters, hepatic matabolism and hepatic efflux transporters on overall hepatic elimination

#129 - EPIDEMGRO

by Serge Savary - 15 runs
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EPIDEMGRO is a generic epidemiological model which simulates plant disease epidemic development over time and accounts for host growth and senescence

#130 - inventory and labor

by David Wheat - 311 runs
Play

#131 - Modelo exponencial

by Carlos Salgado - 22 downloads
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Mortalidad y natalidad dependientes de la densidad tasa de crecimiento per capita constante tasa de crecimiento poblacional proporcional al tamaño de la población independencia entre crecimiento poblacional y densidad

#132 - Ocean Acidification

by Chris - 22 downloads
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Ocean Acidification

#133 - Lake Mono

by Warwick Kelly - 25 downloads
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#134 - Logistic Growth Model and the Butterfly Effect

by Jon Darkow - 168 runs
Play

Model allows users to test the starting population size (N), the carrying capacity of the population (K), and the intrinsic rate of growth (r max). Iterations are discrete, not continuous.

#135 - System Dynamics MFL

by Amin Ganjidoost - 279 runs - 2 downloads
Play

#136 - Urbanseed demo

by Valerie Gacogne - 95 runs
Play

Simulez le nombre de logements que vous pouvez construire sur une emprise donnée (en ha), le nombre d'habitants et les besoins en équipements scolaires résultant. Il s'agit d'une démonstration partielle des potentialités du logiciel Urbanseed.

#137 - MktStructure

by David Wheat - 260 runs
Play

#138 - Mobile Success or failure

by FIT Success or Failure - 24 runs
Play

Three life events that affect a young military members financia well being

#139 - 3 processes DON removal and isotopic fractionnation

by Benoit Thibodeau - 5 runs
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This model simulate the removal of DON by up to 3 different processes with modifiable rate and isotopic fractionation

#140 - Pulse VS patient

by Abbey McDonald - 12 downloads
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FIGHT FIGHT FIGHT

#141 - Timber Harvesting, v0.1

by Dave Zelinka - 18 downloads
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#142 - retailco

by Shamim - 29 runs
Play

This is a Retail Management Simulation. RetailCo has a Voluntary Trading Arrangement Model while its competitors have a business model based on Corporate owned stores.

#143 - Avifauna

by Pablo Reyes Muñoz - 23 downloads
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Modelo básico conceptual de la biología de las aves relacionadas con cambio global

#144 - BigAl

by Stephan Ong - 49 downloads
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Big Al from Mike Pidd (2014)

#145 - School Reform

by isee systems - 51 runs
Play

This Story of the Month reissue examines the complexities of school reform. Inspired by a major school reform effort in Philadelphia, this story explores some of the potential unintended consequences. What happens when the focus of "fixing schools" becomes increasing scores on standardized tests? The Story of the Month series was originally issued starting in May of 2001. While many things have changed since then, many of the issues remain relevant. From corporate corruption, to terrorism, to greenhouse gasses, each story analyzed a past headline news topic from a systems thinking perspective. These topics were modeled using STELLA or iThink with the hopes to gain perspective on the system, stimulate discussion and perhaps adjust our assumptions. isee systems has been re-releasing each Story of the Month from our archives, as originally developed, with an easy-to-access isee Sim Exchange.

#146 - Population Sim with new Methodology

by Corne - 40 runs
Play

This is the simulation that was created with the use of the new methodology of applying system dynamics. A paper is being written about this simulator's construction but here is a basic version of the interface and the effects that can be seen from the structure.

#147 - Model 14. DDI 2 Enzyme Induction

by Sara Rosenbaum - 5 runs
Play

This simulation demonstrates the model used for the induction of the drug metabolizing enzymes. It illustrates how the inducing drug's characteristics (Emax and EC50) control the degree of induction and the rate of degradation of the enzyme controls recove..

#148 - GENEPEST

by Laetitia Willocquet - 65 runs - 2 downloads
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GENEPEST is a generic agrophysiological model which simulates the effects of diseases and pests on crop growth and yield, through damage mechanisms

#149 - Soluzioni che si vendicano

by Carlo Barbati - 35 runs
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Applicazione dell'archetipo FIxes That Fail al caso della manutenzione software presso clienti

#150 - Tolerance-Nicotine- Hypothetical Antagonist

by Sara Rosenbaum - 30 runs
Play

Tolerance may be defined as a process that results in a reduction in the response to a specific drug concentration following repeated drug exposure. One model for tolerance assumes that the drug produces a hypothetical metabolite that opposes its action.

#151 - credit card

by Christopher DiCarlo - 39 downloads
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credit card for 9th grade math class

#152 - West_Kent_Capacity_Model_Demonstration

by Whole Systems Partnership - 146 runs
Play

West Kent bed capacity model demonstration

#153 - limitstogrowth

by Mauricio Uriona - 30 downloads
View

simple model for a resource-constrained population

#154 - ITS

by zbigniew - 47 downloads
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eutrophication

#155 - Population

by Warren Farr - 48 downloads
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#156 - Kent_prototype_population_cohort_model

by Whole Systems Partnership - 213 runs
Play

Kent Prototype Population Cohort Model

#157 - TrainingSim

by Corne - 56 runs
Play

This Simulator investigates the aspects associated with losing and gaining muscle. It reveals the sensitivity of diet and lifestyle changes on muscle formation. It is not a simple system.

#158 - da best cooker

by Oliver Jewell - 38 downloads
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This is a solar cooker made from 1-meter paper panels covered in aluminum foil and tied together with thin rope.

#159 - Population Growth Model

by Stephanie - 41 downloads
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Explaining how the world has grown since billions of years ago. Shows each continents population growth.

#160 - Physiologically Based Pharmacokinetic Model

by Sara Rosenbaum - 72 runs
Play

This model shows how to build a PBPK model and how drug concentrations in different tissues can be simulated

#161 - Pharmacokinetics: An IV Injection on a Two Compartment Model

by Sara Rosenbaum - 58 runs
Play

This model shows the profile of a drug after an intravenous injection when the drug displays two compartment characteristics

#162 - тендер2

by Anton - 217 runs
Play

#163 - hospital-management

by Shamim - 55 runs
Play

This is a simple Learning Lab to explore the impact of capacity management on average length of stay in a hospital.

#164 - Litoral dinámico 03

by Martin Schaffernicht - 44 runs
Play

Versión 3 del modelo de Maullín (Fondef)

#165 - MacroLabData

by David Wheat - 199 runs
Play

historical data only; no model

#166 - AFP

by Martin Schaffernicht - 2 runs
Play

Permite explorar las propuestas de la "Comisión Bravo" acerca de las reformas al sistema previsional de Chile.

#167 - Labour mobility and wage fluctuations

by Crelis Rammelt - 17 runs
Play

#168 - Logistica

by Francisco Vaquera Rivera - 25 downloads
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tarea, ejercicios

#169 - Crecimiento Poblacional

by Lorenzo Andrade - 70 runs
Play

Se trata del modelo básico de crecimiento poblacional, considerando nacimientos y mortalidades.

#170 - YH Chen

by YH Chen - 31 downloads
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#171 - Introduction to Systems Dynamic Modeling

by Will - 17 downloads
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Packet provided after interview

#172 - ClimateThinking

by Steven Hodges - 37 downloads
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A first model Demo. Based on Sterman and Sweeney Booth. Climatic Change (2007) 80:213–238

#173 - Pokemon Go Sim

by Corne - 129 runs
Play

This sim answers the question of how long will it take to reach maximum level

#174 - Mammoth

by Kathy Moore - 11 downloads
View

stock flows in population extinction

#175 - test imlf

by Daniel Churchill - 25 downloads
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#176 - Modeling Salton Sea

by Thiago - 23 downloads
View

ESS 19 HW

#177 - Nora Project 1

by Emre Göktepe - 128 runs - 6 downloads
Download Model Play

#178 - MM-1-1_Growing_linear

by Lavigne - 39 downloads
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Model Mysteries Chapter 1: Growing, Growing, Gone Model 1: Zombie Chickens

#179 - cdxbv m,.-knjb

by Valeria - 21 downloads
View

fgchvjbknlmñ

#180 - Webinar Sim

by Billy Schoenberg - 31 runs
Play

This is the simulation we built during our webinar on 8/23/2016

#181 - DRUGS

by Joshua - 14 downloads
View

Drug rates in hospital

#182 - MM1-2_Growing

by Lavigne - 37 downloads
View

Model Mysteries Chapter 1: Growing, Growing, Gone Model 2: Zombie Chickens

#183 - CWS Reunification - Testing Vouchers at Various Leverage Points

by Saras Chung - 118 runs
Play

This model tests whether housing vouchers in the Child Welfare System are capable of creating faster paths towards reunification for children to their parents.

#184 - EnhancingAnnesModel

by Diana Fisher - 44 downloads
View

This model was copied from Lavigne: We're having fun now!

#185 - D.Eng Video Files

by Sallamar Worrell - 8 runs
Play

These simulation videos represent the user fee sub-systems within the system-level system dynamics model of the FDA medical product review process. The purpose of these models are to illustrate the applicability of the framework presented in my praxis. They are not intended to imply any inefficiencies within the medical product review centers within the FDA or the agency as a whole.

#186 - Cattle Herd Model

by Kanar Dizyee - 69 runs
Play

The users can use herd model to estimate cattle population and farmers profit based on different inputs (mortality, offtake rate, production cost, and cattle prices) inserted by the user.

#187 - test from anne

by Bob Eberlein - 30 downloads
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This model was copied from Lavigne: Model Mysteries Chapter 3: Mind the Gap Dare 3

#188 - EPIDEM

by Serge Savary - 19 runs - 2 downloads
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EPIDEM is a generic epidemiological model which simulates plant disease epidemic development over time

#189 - Extended CLE Model

by Lavigne - 32 downloads
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All the other sims in the book can be done using the free Stella Model Editor.

#190 - MM1-D1_Growing

by Lavigne - 29 downloads
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Model Mysteries Chapter 1: Growing, Growing, Gone Model 3: Zombie Chickens Dare

#191 - Oral Absorption

by Sara Rosenbaum - 127 runs
Play

This model is based on first order absoprtion in a 1-compartment model

#192 - Population demographics with conveyors, v0.1

by Dave Zelinka - 19 downloads
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#193 - water in a lake

by AlexSeibert - 11 downloads
View

water in a lake

#194 - MM2-1_Energy

by Lavigne - 34 downloads
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Model Mysteries Chapter 2: Energy Drink Mania Model 1: Basic Model

#195 - Unreliable forensic kits

by Alan Ticotsky - 31 downloads
View

How police kits produce false positives and lead to wrongful convictions

#196 - Prueba

by Rafael Contreras - 31 downloads
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Esto es una prueba para comprender el funcionamiento de stella simulator

#197 - Population Model

by Demo Account - 38 downloads
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This model was copied from Billy Schoenberg: Demo model

#198 - Peak-Flow Regional Regression Calculator Demonstration 2

by Samuel Austin - 5 runs
Play

A demonstration of peak-flow regional regression calculations in Virginia

#199 - testcld

by Peter Hovmand - 66 downloads
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#200 - da best cooker

by Giuliana Bertoia - 31 downloads
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We are making a solar cooker made out of aluminum foil and cardboard